General Information

    • DRAMP ID

    • DRAMP01514

    • Peptide Name

    • Esculentin-1 (Frogs, amphibians, animals)

    • Source

    • Pelophylax saharicus (Sahara frog) (Rana saharica)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • GIFSKFGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC

    • Sequence Length

    • 46

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • [Ref.8163497] MHC>100 µM against human red blood cell.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Cyclization (Cys40 and Cys46)

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys40 and Cys46.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01514 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01514.

Physicochemical Information

    • Formula

    • C218H376N62O60S3

    • Absent Amino Acids

    • HPQWY

    • Common Amino Acids

    • GK

    • Mass

    • 4921.94

    • PI

    • 9.83

    • Basic Residues

    • 10

    • Acidic Residues

    • 4

    • Hydrophobic Residues

    • 16

    • Net Charge

    • +6

    • Boman Index

    • -47.31

    • Hydrophobicity

    • 0.061

    • Aliphatic Index

    • 103.7

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 2.78

    • Polar Residues

    • 15

DRAMP01514

DRAMP01514 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide (By similarity). Stimulates insulin secretion by BRIN-BD11 cells in vitro.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Skin secretions of Rana saharica frogs reveal antimicrobial peptides esculentins-1 and -1B and brevinins-1E and -2EC with novel insulin releasing activity.

    • Reference

    • J Endocrinol. 2006 Jan;188(1):1-9.

    • Author

    • Marenah L, Flatt PR, Orr DF, Shaw C, Abdel-Wahab YH.