• DRAMP ID

    • DRAMP01517
    • Peptide Name

    • Esculentin-2P (Frogs, amphibians, animals)
    • Source

    • Rana pipiens (northern leopard frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
    • Sequence Length

    • 37
    • Evidence code

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-, Antiviral
    • Target Organism

      • [Ref.10651828]Gram-negative bacterium: Escherichia coli (MIC=10 μM).
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Cyclization (Cys31 and Cys37)
    • Other Modifications and Unusual Amino Acids

    • Disulfide bond between Cys31 and Cys37.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • DRAMP01517 helical wheel diagram
    • Formula

    • C173H290N50O46S2
    • Absent Amino Acids

    • EHMPTWY
    • Common Amino Acids

    • GK
    • Mass

    • 4512.96
    • PI

    • 10.96
    • Basic Residues

    • 7
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 16
    • Boman Index

    • -27.01
    • Hydrophobicity

    • 0.357
    • Aliphatic Index

    • 97.57
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.47
    • Polar Residues

    • 12

DRAMP01517

DRAMP01517 chydropathy plot
    • Function

    • Antibacterial activity against Gram-negative bacteria.
    • Tissue specificity

    • Expressed by the skin glands.
  • ·Literature 1
    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.
    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.