General Information
-
DRAMP ID
- DRAMP01517
-
Peptide Name
- Esculentin-2P (Frogs, amphibians, animals)
-
Source
- Rana pipiens (northern leopard frog)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GFSSIFRGVAKFASKGLGKDLARLGVNLVACKISKQC
-
Sequence Length
- 37
-
Swiss_Prot Entry
- P82846
-
Evidence code
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram-, Antiviral
-
Target Organism
-
- [Ref.10651828]Gram-negative bacterium: Escherichia coli (MIC=10 μM).
-
Hemolytic Activity
-
- N/A
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Free
-
C-terminal Modification
- Cyclization (Cys31 and Cys37)
-
Other Modifications and Unusual Amino Acids
- Disulfide bond between Cys31 and Cys37.
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C173H290N50O46S2
Absent Amino Acids
- EHMPTWY
Common Amino Acids
- GK
Mass
- 4512.96
PI
- 10.96
Basic Residues
- 7
Acidic Residues
- 1
Hydrophobic Residues
- 16
-
Boman Index
- -27.01
Hydrophobicity
- 0.357
Aliphatic Index
- 97.57
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.47
Polar Residues
- 12
DRAMP01517

Comments Information
Function
- Antibacterial activity against Gram-negative bacteria.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
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Pubmed ID
- 10651828
-
Reference
- Eur J Biochem. 2000 Feb;267(3):894-900.
-
Author
- Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.