• DRAMP ID

    • DRAMP01518
    • Peptide Name

    • Esculentin-2L (Frogs, amphibians, animals)
    • Source

    • Rana luteiventris (Great Basin spotted frog)
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Unknown
    • Sequence

    • GILSLFTGGIKALGKTLFKMAGKAGAEHLACKATNQC
    • Sequence Length

    • 37
    • Evidence code

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
    • Target Organism

      • [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 μM);
      • Gram-negative bacterium: Escherichia coli (MIC=6 μM).
      • Yeast: Candida albicans (MIC=53 μM).
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Unknown
    • Structure Description

    • Unknownn
    • DRAMP01518 helical wheel diagram
    • Formula

    • C166H278N46O46S3
    • Absent Amino Acids

    • DPRVWY
    • Common Amino Acids

    • AG
    • Mass

    • 4392.85
    • PI

    • 10.23
    • Basic Residues

    • 6
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 15
    • Boman Index

    • -0.7
    • Hydrophobicity

    • 34.59
    • Aliphatic Index

    • 90
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 3.47
    • Polar Residues

    • 13

DRAMP01518

DRAMP01518 chydropathy plot
    • Function

    • Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Eur J Biochem. 2000 Feb;267(3):894-900.
    • Author

    • Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.
    • Title

    • Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.