General Information
-
DRAMP ID
- DRAMP01518
-
Peptide Name
- Esculentin-2L (Frogs, amphibians, animals)
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Source
- Rana luteiventris (Great Basin spotted frog)
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- GILSLFTGGIKALGKTLFKMAGKAGAEHLACKATNQC
-
Sequence Length
- 37
-
Swiss_Prot Entry
- P82827
-
Evidence code
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
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Target Organism
-
- [Ref.10651828]Gram-positive bacterium: Staphylococcus aureus (MIC=3 μM);
- Gram-negative bacterium: Escherichia coli (MIC=6 μM).
- Yeast: Candida albicans (MIC=53 μM).
-
Hemolytic Activity
-
- Not found
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C166H278N46O46S3
Absent Amino Acids
- DPRVWY
Common Amino Acids
- AG
Mass
- 4392.85
PI
- 10.23
Basic Residues
- 6
Acidic Residues
- 1
Hydrophobic Residues
- 15
-
Boman Index
- -0.7
Hydrophobicity
- 0.346
Aliphatic Index
- 90
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 125
Absorbance 280nm
- 3.47
Polar Residues
- 13
DRAMP01518

Comments Information
Function
- Antimicrobial activity against the Gram-positive, Gram-negative bacteria and fungi.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens.
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Pubmed ID
- 10651828
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Reference
- Eur J Biochem. 2000 Feb;267(3):894-900.
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Author
- Goraya J, Wang Y, Li Z, O'Flaherty M, Knoop FC, Platz JE, Conlon JM.