General Information

    • DRAMP ID

    • DRAMP01523

    • Peptide Name

    • Rugosin A-like peptide (Frogs, amphibians, animals)

    • Source

    • Rana saharica (Sahara frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • KGAAKGLLEVASCKLSKSC

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01523 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01523.

Physicochemical Information

    • Formula

    • C80H145N23O25S2

    • Absent Amino Acids

    • DFHIMNPQRTWY

    • Common Amino Acids

    • K

    • Mass

    • 1893.29

    • PI

    • 9.31

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • -10.54

    • Hydrophobicity

    • 0.195

    • Aliphatic Index

    • 92.63

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 125

    • Absorbance 280nm

    • 6.94

    • Polar Residues

    • 7

DRAMP01523

DRAMP01523 chydropathy plot

Comments Information

    • Function

    • Stimulates insulin secretion by BRIN-BD11 cells in vitro. Has antibacterial activity.

    • Tissue specificity

    • Expressed by the skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and structural characterization of novel Rugosin A-like insulinotropic peptide from the skin secretions of Rana saharica frog.

    • Reference

    • Peptides. 2005 Nov;26(11):2117-2123.

    • Author

    • Marenah L, Flatt P.R, Orr D.F, Shaw C, Abdel-Wahab Y.H.A.