General Information

    • DRAMP ID

    • DRAMP01539

    • Peptide Name

    • Nigroain-C2 (Frogs, amphibians, animals)

    • Source

    • Rana nigrovittata (Black-striped frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FKTWKRPPFQTSCWGIIKE

    • Sequence Length

    • 19

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus ATCC25923 (MIC=27.50 µg/ml), S. aureus ATCC43300 (MIC=55.00 µg/ml), Bacillus subtilis (MIC=110.00 µg/ml);
      • Gram-negative bacteria: Escherichia coli ML-35P (MIC=110.00 µg/ml), Pseudomonas aeruginosa PA01 (MIC=55.00 µg/ml), Pseudomonas aeruginosa ATCC27853 (MIC=55.00 µg/ml).
      • Yeast: Candida albicans ATCC2002 (MIC=13.75 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01539 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01539.

Physicochemical Information

    • Formula

    • C112H166N28O26S

    • Absent Amino Acids

    • ADHLMNVY

    • Common Amino Acids

    • K

    • Mass

    • 2352.78

    • PI

    • 9.79

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +3

    • Boman Index

    • -29.78

    • Hydrophobicity

    • -0.721

    • Aliphatic Index

    • 41.05

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 611.11

    • Polar Residues

    • 5

DRAMP01539

DRAMP01539 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.

    • Reference

    • Genomics. 2010 Jan;95(1):66-71.

    • Author

    • Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R.