General Information

    • DRAMP ID

    • DRAMP01542

    • Peptide Name

    • Nigroain-D3 (Frogs, amphibians, animals)

    • Source

    • Rana nigrovittata (Black-striped frog)

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • CVHWQTNTARTSCIGP

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Bacillus subtilis (MIC=55 µg/ml).
      • Yeast: Candida albicans ATCC2002 (MIC=110 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Cyclization (Cys1 and Cys13)

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bridge between Cys1 and Cys13.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01542 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01542.

Physicochemical Information

    • Formula

    • C74H116N24O23S2

    • Absent Amino Acids

    • DEFKLMY

    • Common Amino Acids

    • T

    • Mass

    • 1774

    • PI

    • 8.08

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • +2

    • Boman Index

    • -26.27

    • Hydrophobicity

    • -0.313

    • Aliphatic Index

    • 48.75

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 375

    • Polar Residues

    • 8

DRAMP01542

Comments Information

    • PTM

    • Contains one disulfide bridge.

Literature Information

  • ·Literature 1

    • Title

    • Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.

    • Reference

    • Genomics. 2010 Jan;95(1):66-71.

    • Author

    • Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R.