• DRAMP ID

    • DRAMP01543
    • Peptide Name

    • Nigroain-E1 (Frogs, amphibians, animals)
    • Source

    • Rana nigrovittata (Black-striped frog)
    • Family

    • Not found
    • Gene

    • Not found
    • Sequence

    • DCTRWIIGINGRICRD
    • Sequence Length

    • 16
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Antifungal
    • Target Organism

      • [Ref.19778602]Gram-positive bacterium: Staphylococcus aureus ATCC25923 (MIC=18.75 µg/ml);
      • Yeast: Candida albicans ATCC2002 (MIC=75 µg/ml).
    • Hemolytic Activity

      • [Ref:19778602]7.62±1.6% hemolytic activity at 100 µg/ml against rabbit red cells
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bridge between Cys2 and Cys14.
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01543 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01543.
    • Formula

    • C79H131N27O23S2
    • Absent Amino Acids

    • AEFHKLMPQSVY
    • Common Amino Acids

    • I
    • Mass

    • 1891.2
    • PI

    • 8.07
    • Basic Residues

    • 3
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 5
    • Net Charge

    • +1
    • Boman Index

    • -44.96
    • Hydrophobicity

    • -0.213
    • Aliphatic Index

    • 97.5
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 375
    • Polar Residues

    • 6

DRAMP01543

    • Function

    • Has hemolytic activity against rabbit red cells.
  • ·Literature 1
    • Title

    • Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata.
    • Reference

    • Genomics. 2010 Jan;95(1):66-71.
    • Author

    • Ma Y, Liu C, Liu X, Wu J, Yang H, Wang Y, Li J, Yu H, Lai R.