General Information

    • DRAMP ID

    • DRAMP01556

    • Peptide Name

    • Caerin-1.6 (Frogs, amphibians, animals)

    • Source

    • Litoria xanthomera (Orange-thighed frog) (Litoria chloris)

    • Family

    • Belongs to the frog skin active peptide family (Caerin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLFSVLGAVAKHVLPHVVPVIAEKL

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial,Antiviral

    • Target Organism

      • [Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.26026377]Human endocervical cells End1/E6E7:50% cell death at 10 µM.

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01556 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01556.

Physicochemical Information

    • Formula

    • C124H205N31O29

    • Absent Amino Acids

    • CDMNQRTWY

    • Common Amino Acids

    • V

    • Mass

    • 2594.18

    • PI

    • 8.61

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 15

    • Net Charge

    • +3

    • Boman Index

    • 28.5

    • Hydrophobicity

    • 1.224

    • Aliphatic Index

    • 159.6

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01556

DRAMP01556 chydropathy plot

Comments Information

    • Function

    • Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

    • Domain

    • Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility By similarity.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Inhibition of HIV infection by caerin 1 antimicrobial peptides.

    • Reference

    • Peptides. 2015 Sep;71:296-303.

    • Author

    • VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.
  • ·Literature 2

    • Title

    • New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.

    • Reference

    • J Pept Sci. 1997 May-Jun;3(3):181-185.

    • Author

    • Steinborner ST, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ, Ramsay SL.
  • ·Literature 3

    • Title

    • New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera. Part 2. Sequence determination using mass spectrometry and associated techniques.

    • Reference

    • Rapid Commun Mass Spectrom. 1997;11(9):997-1000.

    • Author

    • Steinborner ST, Waugh RJ, Bowie JH, Tyler MJ.
  • ·Literature 4

    • Title

    • New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria.

    • Reference

    • J Pept Res. 1998 Feb;51(2):121-126.

    • Author

    • Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ.