General Information
-
DRAMP ID
- DRAMP01559
-
Peptide Name
- Caerin-1.8 (Frogs, amphibians, animals)
-
Source
- Litoria chloris (Blue-thighed frog)
-
Family
- Belongs to the frog skin active peptide family (Caerin subfamily)
-
Gene
- Not found
-
Sequence
- GLFKVLGSVAKHLLPHVVPVIAEKL
-
Sequence Length
- 25
-
UniProt Entry
- P81251
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Antifungal, Antiviral
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Target Organism
- Litoria chloris
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Alpha helix
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01559.
Physicochemical Information
-
Formula
- C128H214N32O29
Absent Amino Acids
- CDMNQRTWY
Common Amino Acids
- LV
Mass
- 2665.3
PI
- 9.7
Basic Residues
- 5
Acidic Residues
- 1
Hydrophobic Residues
- 14
Net Charge
- +4
-
Boman Index
- 22.02
Hydrophobicity
- 0.98
Aliphatic Index
- 159.6
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP01559
Comments Information
Function
- Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity
- Expressed by the skin dorsal glands.
Domain
- Contains two amphipathic alpha helix regions separated by a region of less-defined helicity and greater flexibility (By similarity).
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
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Title
- New antibiotic caerin 1 peptides from the skin secretion of the Australian tree frog Litoria chloris. Comparison of the activities of the caerin 1 peptides from the genus Litoria.
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Pubmed ID
- 9516047
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Reference
- J Pept Res. 1998 Feb;51(2):121-126.
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Author
- Steinborner ST, Currie GJ, Bowie JH, Wallace JC, Tyler MJ.