General Information
-
DRAMP ID
- DRAMP01568
-
Peptide Name
- Caerin-2.7 (Frogs, amphibians, animals)
-
Source
- the skin secretions) (hybrid between female Litoria splendida; also male Litoria caerulea
-
Family
- Belongs to the frog skin active peptide family (Caerin subfamily)
-
Gene
- Not found
-
Sequence
- GLVSSIGKALGGLLVDVVKSKGQPA
-
Sequence Length
- 25
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
-
Target Organism
-
- Gram-positive bacterium: Leuconostoc lactis (MIC=50 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01568.
Physicochemical Information
-
Formula
- C107H189N29O32
Absent Amino Acids
- CEFHMNRTWY
Common Amino Acids
- G
Mass
- 2393.85
PI
- 9.7
Basic Residues
- 3
Acidic Residues
- 1
Hydrophobic Residues
- 11
Net Charge
- +2
-
Boman Index
- 7.97
Hydrophobicity
- 0.616
Aliphatic Index
- 132.4
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 8
DRAMP01568
Comments Information
Function
- Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity (By similarity).
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
-
Title
- Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea.
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Pubmed ID
- 16824041
-
Reference
- FEBS J. 2006 Aug;273(15):3511-3519.
-
Author
- Pukala TL, Bertozzi T, Donnellan SC, Bowie JH, Surinya-Johnson KH, Liu Y, Jackway RJ, Doyle JR, Llewellyn LE, Tyler MJ.