General Information

    • DRAMP ID

    • DRAMP01568

    • Peptide Name

    • Caerin-2.7 (Frogs, amphibians, animals)

    • Source

    • the skin secretions) (hybrid between female Litoria splendida; also male Litoria caerulea

    • Family

    • Belongs to the frog skin active peptide family (Caerin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLVSSIGKALGGLLVDVVKSKGQPA

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Leuconostoc lactis (MIC=50 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01568 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01568.

Physicochemical Information

    • Formula

    • C107H189N29O32

    • Absent Amino Acids

    • CEFHMNRTWY

    • Common Amino Acids

    • G

    • Mass

    • 2393.85

    • PI

    • 9.7

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 11

    • Net Charge

    • +2

    • Boman Index

    • 7.97

    • Hydrophobicity

    • 0.616

    • Aliphatic Index

    • 132.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 8

DRAMP01568

DRAMP01568 chydropathy plot

Comments Information

    • Function

    • Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity (By similarity).

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Host-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea.

    • Reference

    • FEBS J. 2006 Aug;273(15):3511-3519.

    • Author

    • Pukala TL, Bertozzi T, Donnellan SC, Bowie JH, Surinya-Johnson KH, Liu Y, Jackway RJ, Doyle JR, Llewellyn LE, Tyler MJ.