• • DRAMP ID

  • DRAMP01569

• • Peptide Name

  • Caerin-3.1 (Frogs, amphibians, animals)

• • Source

  • Litoria gilleni (Centralian tree frog) (Litoria splendida) (Litoria rothii)

• • Family

  • Belongs to the frog skin active peptide family (Caerin subfamily)

• • Gene

  • Not found

• • Sequence

  • GLWQKIKDKASELVSGIVEGVK

• • Sequence Length

  • 22

• • UniProt Entry

  • P62562,P56238,P62563,P86505

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+

• • Target Organism

  • • Gram-positive bacterium: Micrococcus luteus (MIC<0.4 µg/ml). (Ref.2)

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01569.

DRAMP01569

• • Function

  • Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.

• • Tissue specificity

  • Expressed by the skin parotoid and/or rostral glands.

• • PTM

  • C-terminal amidation.

• ·Literature 1

• • Title

  • Peptides from Australian frogs. The structures of the caerins from Litoria caerula.

• • Pubmed ID

  • PubMed ID is not available

• • Reference

  • J. Chem. Res. 1993; 138: 910-936.

• • Author

  • Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.

• ·Literature 2

• • Title

  • Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.

• • Pubmed ID

  • 15203252

• • Reference

  • Peptides. 2004 Jun;25(6):1035-1054.

• • Author

  • Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.

• ·Literature 3

• • Title

  • The rothein peptides from the skin secretion of Roth's tree frog Litoria rothii. Sequence determination using positive and negative ion electrospray mass spectrometry.

• • Pubmed ID

  • 16124032

• • Reference

  • Rapid Commun Mass Spectrom. 2005;19(18):2716-2724.

• • Author

  • Brinkworth CS, Bowie JH, Bilusich D, Tyler MJ.

• ·Literature 4

• • Title

  • Activities of seasonably variable caerulein and rothein skin peptides from the tree frogs Litoria splendida and Litoria rothii.

• • Pubmed ID

  • 195396

• • Reference

  • Toxicon. 2009 Nov;54(6):828-835.

• • Author

  • Sherman PJ, Jackway RJ, Nicholson E, Musgrave IF, Boontheung P, Bowie JH.