General Information
-
DRAMP ID
- DRAMP01571
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Peptide Name
- Caerin-3.3 (Frogs, amphibians, animals)
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Source
- Litoria caerulea (Green tree frog)
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Family
- Belongs to the frog skin active peptide family (Caerin subfamily)
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Gene
- Not found
-
Sequence
- GLWEKIKEKANELVSGIVEGVK
-
Sequence Length
- 22
-
UniProt Entry
- P56240
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP01571.
Physicochemical Information
-
Formula
- C110H184N28O33
Absent Amino Acids
- CDFHMPQRTY
Common Amino Acids
- EK
Mass
- 2426.84
PI
- 6.29
Basic Residues
- 4
Acidic Residues
- 4
Hydrophobic Residues
- 9
Net Charge
- 0
-
Boman Index
- -20.72
Hydrophobicity
- -0.227
Aliphatic Index
- 115
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 261.9
Polar Residues
- 5
DRAMP01571
Comments Information
Function
- Antibacterial peptide, that adopts an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
Tissue specificity
- Expressed by the skin parotoid and/or rostral glands.
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
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Title
- Peptides from Australian frogs. The structures of the caerins from Litoria caerula.
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Pubmed ID
- PubMed ID is not available
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Reference
- J. Chem. Res. 1993; 138: 910-936.
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Author
- Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.