General Information
-
DRAMP ID
- DRAMP01573
-
Peptide Name
- Caerin-3.5 (Frogs, amphibians, animals)
-
Source
- Litoria gracilenta (Dainty green tree frog)
-
Family
- Belongs to the frog skin active peptide family (Caerin subfamily)
-
Gene
- Not found
-
Sequence
- GLWEKVKEKANELVSGIVEGVK
-
Sequence Length
- 22
-
UniProt Entry
- P0C2A9
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacterium: Leuconostoc lactis (MIC=100 µg/ml).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01573.
Physicochemical Information
-
Formula
- C109H182N28O33
Absent Amino Acids
- CDFHMPQRTY
Common Amino Acids
- EKV
Mass
- 2412.81
PI
- 6.29
Basic Residues
- 4
Acidic Residues
- 4
Hydrophobic Residues
- 9
Net Charge
- 0
-
Boman Index
- -21.6
Hydrophobicity
- -0.241
Aliphatic Index
- 110.45
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 261.9
Polar Residues
- 5
DRAMP01573
Comments Information
Function
- Shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms.
Tissue specificity
- Expressed by the skin dorsal glands.
Literature Information
- ·Literature 1
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Title
- New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry.
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Pubmed ID
- 16554081
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Reference
- Toxicon. 2006 May;47(6):664-675.
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Author
- Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ.