• DRAMP ID

    • DRAMP01574
    • Peptide Name

    • Caerin-4.1 (Frogs, amphibians, animals)
    • Source

    • Litoria caerulea (Green tree frog)
    • Family

    • Belongs to the frog skin active peptide family (Caerin subfamily)
    • Gene

    • Unknow
    • Sequence

    • GLWQKIKSAAGDLASGIVEGIKS
    • Sequence Length

    • 23
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antiviral
    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus (MIC=12 µg/ml);
      • Gram-negative bacterium: Escherichia coli (MIC=25 µg/ml).(Ref.2)
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Alpha helix
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP01574 helical wheel diagram
    • Formula

    • C104H174N28O32
    • Absent Amino Acids

    • CFHMNPRTY
    • Common Amino Acids

    • G
    • Mass

    • 2721.31
    • PI

    • 9.44
    • Basic Residues

    • 3
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 10
    • Boman Index

    • -7.76
    • Hydrophobicity

    • 15.65
    • Aliphatic Index

    • 110.43
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 250
    • Polar Residues

    • 7

DRAMP01574

DRAMP01574 chydropathy plot
    • PTM

    • adopt an alpha helical conformation which can disrupt bacterial membranes. Each caerin displays a different antimicrobial specificity.
    • Tissue specificity

    • Expressed by the skin parotoid and/or rostral glands.
  • Literature 1
    • Reference

    • J. Chem. Res. 1993; 138: 910-936.
    • Author

    • Stone DJM, Waugh RJ, Bowie JH, Wallace JC, Tyler MJ.
    • Title

    • Peptides from Australian frogs. The structures of the caerins from Litoria caerula.
  • Literature 2
    • Reference

    • Peptides. 2004 Jun;25(6):1035-1054.
    • Author

    • Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.
    • Title

    • Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.