General Information

    • DRAMP ID

    • DRAMP01585

    • Peptide Name

    • Caerin-1.18 (Frogs, amphibians, animals)

    • Source

    • Litoria gracilenta (Dainty green tree frog)

    • Family

    • Belongs to the frog skin active peptide family (Caerin subfamily)

    • Gene

    • Not found

    • Sequence

    • GLFSVLGSVAKHLLPHVVPVIAEKL

    • Sequence Length

    • 25

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=50 µg/ml), Leuconostoc lactis (MIC=25 µg/ml), Listeria innocua (MIC=12 µg/ml), Micrococcus luteus (MIC=12 µg/ml), Staphylococcus aureus ATCC 25923 (MIC=12 µg/ml), Staphylococcus aureus ATCC 29213 (MIC=12 µg/ml), Staphylococcus epidermidis (MIC=25 µg/ml), Streptococcus uberis (MIC=25 µg/ml);
      • Gram-negative bacteria: Pasteurella multocida (MIC=50 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01585 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01585.

Physicochemical Information

    • Formula

    • C125H207N31O30

    • Absent Amino Acids

    • CDMNQRTWY

    • Common Amino Acids

    • LV

    • Mass

    • 2624.21

    • PI

    • 8.61

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • 24.17

    • Hydrophobicity

    • 1.104

    • Aliphatic Index

    • 159.6

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01585

DRAMP01585 chydropathy plot

Comments Information

    • Function

    • Shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms.

    • Tissue specificity

    • Expressed by the skin dorsal glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry.

    • Reference

    • Toxicon. 2006 May;47(6):664-675.

    • Author

    • Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ.