• • DRAMP ID

  • DRAMP01586

• • Peptide Name

  • Caerin-1.19 (Frogs, amphibians, animals)

• • Source

  • Litoria gracilenta (Dainty green tree frog)

• • Family

  • Belongs to the frog skin active peptide family (Caerin subfamily)

• • Gene

  • Not found

• • Sequence

  • GLFKVLGSVAKHLLPHVAPIIAEKL

• • Sequence Length

  • 25

• • UniProt Entry

  • P0C2A8

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-,Antiviral

• • Target Organism

  • • [Ref.16554081]Gram-positive bacteria: Bacillus cereus (MIC=50 µg/ml), Leuconostoc lactis (MIC=3 µg/ml), Listeria innocua (MIC=12 µg/ml), Micrococcus luteus (MIC=25 µg/ml), Staphylococcus aureus Strain ATCC 25923 (MIC=12 µg/ml), Staphylococcus aureus Strain ATCC 29213 (MIC=12 µg/ml), Staphylococcus epidermidis (MIC=12 µg/ml), Streptococcus uberis (MIC=25 µg/ml);
    • Gram-negative bacteria: Pasteurella multocida (MIC=50 µg/ml).
    • [Ref.26026377]Virus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=2.5 µM).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01586.

DRAMP01586

• • Function

  • Caerin-1.19 shows significant activity against Gram-positive organisms, but is less effective against Gram-negative organisms.

• • Tissue specificity

  • Expressed by the skin dorsal glands.

• • PTM

  • C-terminal amidation.

• ·Literature 1

• • Title

  • Inhibition of HIV infection by caerin 1 antimicrobial peptides.

• • Pubmed ID

  • 26026377

• • Reference

  • Peptides. 2015 Sep;71:296-303.

• • Author

  • VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

• ·Literature 2

• • Title

  • New caerin antibiotic peptides from the skin secretion of the Dainty Green Tree Frog Litoria gracilenta. Identification using positive and negative ion electrospray mass spectrometry.

• • Pubmed ID

  • 16554081

• • Reference

  • Toxicon. 2006 May;47(6):664-675.

• • Author

  • Maclean MJ, Brinkworth CS, Bilusich D, Bowie JH, Doyle JR, Llewellyn LE, Tyler MJ.