General Information

    • DRAMP ID

    • DRAMP01589

    • Peptide Name

    • Citropin-1.1 sm2 (Frogs, amphibians, animals)

    • Source

    • Synthesized modify

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • GLFDVIAKVASVIGGL

    • Sequence Length

    • 16

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Synthetic

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus cereus (MIC=100 µg/ml), Leuconostoc lactis (MIC=25 µg/ml), Micrococcus luteus (MIC=100 µg/ml), Staphylococcus aureus (MIC=100 µg/ml), Staphylococcus epidermidis (MIC=100 µg/ml), Streptococcus uberis (MIC=100 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01589 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01589.

Physicochemical Information

    • Formula

    • C73H123N17O20

    • Absent Amino Acids

    • CEHMNPQRTWY

    • Common Amino Acids

    • GV

    • Mass

    • 1558.88

    • PI

    • 5.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • 0

    • Boman Index

    • 23.55

    • Hydrophobicity

    • 1.638

    • Aliphatic Index

    • 164.38

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01589

Comments Information

    • Function

    • Amphibian defensive peptide.

    • Tissue specificity

    • Expressed by the dorsal and submental skin glands.

Literature Information

  • ·Literature 1

    • Title

    • Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.

    • Reference

    • Eur J Biochem. 1999 Oct;265(2):627-637.

    • Author

    • Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ.