General Information
-
DRAMP ID
- DRAMP01600
-
Peptide Name
- Citropin-1.3 (Frogs, amphibians, animals)
-
Source
- Litoria citropa (Australian blue mountains tree frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GLFDIIKKVASVIGGL
-
Sequence Length
- 16
-
UniProt Entry
- P81846
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Bacillus cereus (MIC=25 µg/ml), Leuconostoc lactis (MIC=6 µg/ml), Listeria innocua (MIC=25 µg/ml), Micrococcus luteus (MIC=12 µg/ml), Staphylococcus aureus (MIC=25 µg/ml), Staphylococcus epidermidis (MIC=25 µg/ml), Streptococcus uberis (MIC=25 µg/ml). (Ref.2)
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01600.
Physicochemical Information
-
Formula
- C77H132N18O20
Absent Amino Acids
- CEHMNPQRTWY
Common Amino Acids
- GI
Mass
- 1630
PI
- 8.59
Basic Residues
- 2
Acidic Residues
- 1
Hydrophobic Residues
- 9
Net Charge
- +1
-
Boman Index
- 17.07
Hydrophobicity
- 1.3
Aliphatic Index
- 164.38
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP01600
Comments Information
Function
- Amphibian defensive peptide.
Tissue specificity
- Expressed by the dorsal and submental skin glands.
Literature Information
- ·Literature 1
-
Title
- Host defence peptides from the skin glands of the Australian blue mountains tree-frog Litoria citropa. Solution structure of the antibacterial peptide citropin 1.1.
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Pubmed ID
- 10504394
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Reference
- Eur J Biochem. 1999 Oct;265(2):627-637.
-
Author
- Wegener KL, Wabnitz PA, Carver JA, Bowie JH, Chia BC, Wallace JC, Tyler MJ.
- ·Literature 2
-
Title
- Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.
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Pubmed ID
- 15203252
-
Reference
- Peptides. 2004 Jun;25(6):1035-1054.
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Author
- Apponyi MA, Pukala TL, Brinkworth CS, Maselli VM, Bowie JH, Tyler MJ, Booker GW, Wallace JC, Carver JA, Separovic F, Doyle J, Llewellyn LE.