General Information

    • DRAMP ID

    • DRAMP01621

    • Peptide Name

    • Bombinin-H1 (Frogs, amphibians, animals)

    • Source

    • Bombina variegata (European frog)

    • Family

    • Belongs to the bombinin family

    • Gene

    • Not found

    • Sequence

    • IIGPVLGMVGSALGGLLKKI

    • Sequence Length

    • 20

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=3.8 µM);
      • Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=2.1 µM).

    • Hemolytic Activity

      • [Ref:8223491]Not determined hemolytic activity against human red blood cells.

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01621 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01621.

Physicochemical Information

    • Formula

    • C90H162N22O22S

    • Absent Amino Acids

    • CDEFHNQRTWY

    • Common Amino Acids

    • G

    • Mass

    • 1936.47

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +2

    • Boman Index

    • 36.88

    • Hydrophobicity

    • 1.43

    • Aliphatic Index

    • 170.5

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP01621

DRAMP01621 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation and D-amino acid.

Literature Information

  • ·Literature 1

    • Title

    • Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.

    • Reference

    • EMBO J. 1993 Dec;12(12):4829-4832.

    • Author

    • Mignogna G, Simmaco M, Kreil G, Barra D.