• • DRAMP ID

  • DRAMP01623

• • Peptide Name

  • Bombinin-H4 (bombinin H isomers; Frogs, amphibians, animals)

• • Source

  • Bombina variegata (European frog)

• • Family

  • Belongs to the bombinin family

• • Gene

  • Not found

• • Sequence

  • LIGPVLGLVGSALGGLLKKI

• • Sequence Length

  • 20

• • UniProt Entry

  • P82284

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, hemolytic against mammalian cells, Antifungal

• • Target Organism

  • • [Ref.8223491] Gram-negative bacterium: Escherichia coli D21 (MIC=4.8 µM);
    • Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.3 µM).

• • Hemolytic Activity

  • • [Ref.8223491] Lethal concentration is 14.6 µM against human red blood cell.

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • The epimerization reaction is incomplete, or, after racemization, the peptides still containing the L-amino acid in position 2 are partly degraded.

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP01623_predicted_structure.pdb to download.

DRAMP01623

• • Function

  • Have antimicrobial activity. Have some hemolytic activity.

• ·Literature 1

• • Title

  • Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.

• • Pubmed ID

  • 8223491

• • Reference

  • EMBO J. 1993; 12:4829-4832.

• • Author

  • Mignogna G, Simmaco M, Kreil G, Barra D.1993