• DRAMP ID

    • DRAMP01626
    • Peptide Name

    • Bombinin-H5 (Frogs, amphibians, animals)
    • Source

    • Bombina variegata (European frog)
    • Family

    • Belongs to the bombinin family
    • Gene

    • Not found
    • Sequence

    • IIGPVLGLVGSALGGLLKKI
    • Sequence Length

    • 20
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.8223491]Gram-negative bacterium: Escherichia coli D21 (MIC=5.0 µM);
      • Gram-positive bacterium: Staphylococcus aureus Cowan 1 (MIC=3.0 µM).
    • Hemolytic Activity

      • [Ref:8223491]Not found
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • Mixed (2D-aIle(alloisoleucine))
    • Structure

    • Alpha helix (1 helices; 16 residues)
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01626 helical wheel diagram
  • 2AP7-> 
    • Predicted Structure

    • Formula

    • C91H164N22O22
    • Absent Amino Acids

    • CDEFHMNQRTWY
    • Common Amino Acids

    • GL
    • Mass

    • 1918.44
    • PI

    • 10
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +2
    • Boman Index

    • 39.45
    • Hydrophobicity

    • 1.525
    • Aliphatic Index

    • 190
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 6

DRAMP01626

DRAMP01626 chydropathy plot
    • Function

    • Has antimicrobial activity.
    • Tissue specificity

    • Expressed by the skin glands.
    • PTM

    • C-terminal amidation and D-amino acid.
  • ·Literature 1
    • Title

    • Antibacterial and haemolytic peptides containing D-alloisoleucine from the skin of Bombina variegata.
    • Reference

    • EMBO J. 1993 Dec;12(12):4829-4832
    • Author

    • Mignogna G, Simmaco M, Kreil G, Barra D.
  • ·Literature 2
    • Title

    • Solution structure and orientation of bombinin H2 and H4 in a membrane-mimetic environment.
    • Reference

    • TO BE PUBLISHED
    • Author

    • Zangger K, Jilek A, Khatai L.