General Information

    • DRAMP ID

    • DRAMP01628

    • Peptide Name

    • Phylloxin (Frogs, amphibians, animals)

    • Source

    • Phyllomedusa bicolor (Two-colored leaf frog)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • PLX

    • Sequence

    • GWMSKIASGIGTFLSGMQQ

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Acholeplasma laidlawii A-PG8 (MIC=12.5 µM), Spiroplasma melliferum BC3 (MIC=50 µM), Rhizobium meliloti 102F34 (MIC=12.5 µM), Escherichia coli K12 (MIC=10 µM);
      • Gram-positive bacteria: Bacillus megaterium KM (MIC=3.12 µM), Corynebacterium glutamicum ATCC 27853 (MIC=1.56 µM), Micrococcus luteus ATCC 27853 (MIC=3.0 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01628 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01628.

Physicochemical Information

    • Formula

    • C88H139N23O26S2

    • Absent Amino Acids

    • CDEHNPRVY

    • Common Amino Acids

    • G

    • Mass

    • 1999.33

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • 0.94

    • Hydrophobicity

    • 0.247

    • Aliphatic Index

    • 66.84

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 305.56

    • Polar Residues

    • 8

DRAMP01628

DRAMP01628 chydropathy plot

Comments Information

    • Function

    • Antimicrobial peptide against the Gram-positive bacteria and the Gram-negative-bacteria.

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors.

    • Reference

    • Eur J Biochem. 2000 Jan;267(2):370-378.

    • Author

    • Pierre TN, Seon AA, Amiche M, Nicolas P.