General Information
-
DRAMP ID
- DRAMP01645
-
Peptide Name
- Dermaseptin-7 (DShypo07; Frogs, amphibians, animals)
-
Source
- Phyllomedusa hypochondrialis (Orange-legged leaf frog)
-
Family
- Not found
-
Gene
- Not found
-
Sequence
- GLWSTIKQKGKEAAIAAAKAAGQAALNAASEAL
-
Sequence Length
- 33
-
UniProt Entry
- P84880
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial
-
Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01645.
Physicochemical Information
-
Formula
- C141H237N41O44
Absent Amino Acids
- CDFHMPRVY
Common Amino Acids
- A
Mass
- 3210.68
PI
- 9.53
Basic Residues
- 4
Acidic Residues
- 2
Hydrophobic Residues
- 18
Net Charge
- +2
-
Boman Index
- -11.44
Hydrophobicity
- 0.136
Aliphatic Index
- 95.45
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 171.88
Polar Residues
- 7
DRAMP01645
Comments Information
Function
- Has antimicrobial activity.
Tissue specificity
- Expressed by the skin glands.
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
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Title
- Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia).
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Pubmed ID
- 16844081
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Reference
- Biochem Biophys Res Commun. 2006 Sep 1;347(3):739-746.
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Author
- Brand GD, Leite JR, de Sá Mandel SM, Mesquita DA, Silva LP, Prates MV, Barbosa EA, Vinecky F, Martins GR, Galasso JH, Kuckelhaus SA, Sampaio RN, Furtado JR Jr, Andrade AC, Bloch C Jr.