General Information

    • DRAMP ID

    • DRAMP01647

    • Peptide Name

    • DRP-PBN1 (Frogs, amphibians, animals)

    • Source

    • Phyllomedusa bicolor

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • FLSLIPHIVSGVAALAKHLG

    • Sequence Length

    • 20

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: S. aureus (MIC=12 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01647 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01647.

Physicochemical Information

    • Formula

    • C97H159N25O23

    • Absent Amino Acids

    • CDEMNQRTWY

    • Common Amino Acids

    • L

    • Mass

    • 2043.48

    • PI

    • 8.76

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +3

    • Boman Index

    • 26.22

    • Hydrophobicity

    • 1.325

    • Aliphatic Index

    • 161

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01647

DRAMP01647 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Membrane association, electrostatic sequestration, and cytotoxicity of Gly-Leu-rich peptide orthologs with differing functions.

    • Reference

    • Biochemistry. 2004 Jul 6;43(26):8391-8409.

    • Author

    • Vanhoye D, Bruston F, El Amri S, Ladram A, Amiche M, Nicolas P.