General Information

    • DRAMP ID

    • DRAMP01655

    • Peptide Name

    • Dermaseptin DRG1 (Dermaseptin-1; Dermaseptin-B7, DRS-B7; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • DRG1

    • Sequence

    • GLWSNIKTAGKEAAKAALKAAGKAALGAVTDAV

    • Sequence Length

    • 33

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01655 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01655.

Physicochemical Information

    • Formula

    • C140H238N40O42

    • Absent Amino Acids

    • CFHMPQRY

    • Common Amino Acids

    • A

    • Mass

    • 3153.67

    • PI

    • 9.83

    • Basic Residues

    • 5

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 18

    • Net Charge

    • +3

    • Boman Index

    • -4.7

    • Hydrophobicity

    • 0.285

    • Aliphatic Index

    • 98.18

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 171.88

    • Polar Residues

    • 8

DRAMP01655

DRAMP01655 chydropathy plot

Comments Information

    • Function

    • Has antimicrobial activity (Potential).

    • Tissue specificity

    • Expressed by the skin glands.

    • PTM

    • C-terminal amidation.

Literature Information

  • ·Literature 1

    • Title

    • Unknown

    • Reference

    • Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases

    • Author

    • Amiche M.