General Information
-
DRAMP ID
- DRAMP01665
-
Peptide Name
- Dermaseptin-J8 (DRS-J8; Frogs, amphibians, animals)
-
Source
- Phasmahyla jandaia (Jandaia leaf frog)
-
Family
- Belongs to the frog skin active peptide family (Dermaseptin subfamily)
-
Gene
- Not found
-
Sequence
- GLWKSLLKNVGKAAGKAALNAVTDMVNQA
-
Sequence Length
- 29
-
UniProt Entry
- P86640
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01665.
Physicochemical Information
-
Formula
- C131H222N38O38S
Absent Amino Acids
- CEFHIPRY
Common Amino Acids
- A
Mass
- 2969.5
PI
- 10
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 14
Net Charge
- +3
-
Boman Index
- -12.19
Hydrophobicity
- 0.131
Aliphatic Index
- 104.48
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 196.43
Polar Residues
- 8
DRAMP01665
Comments Information
Function
- Antimicrobial peptide.
Tissue specificity
- Expressed by the skin glands.
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
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Title
- Peptidomic dissection of the skin secretion of Phasmahyla jandaia (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).
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Pubmed ID
- 20932854
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Reference
- Toxicon. 2011 Jan;57(1):35-52.
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Author
- Rates B, Silva LP, Ireno IC, Leite FS, Borges MH, Bloch C Jr, De Lima ME, Pimenta AM.