• • DRAMP ID

  • DRAMP01668

• • Peptide Name

  • Dermaseptin-1 (DS I; Dermaseptin-S1, DS1; Frogs, amphibians, animals)

• • Source

  • Phyllomedusa sauvagei (Sauvage's leaf frog)

• • Family

  • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

• • Gene

  • Not found

• • Sequence

  • ALWKTMLKKLGTMALHAGKAALGAAADTISQGTQ

• • Sequence Length

  • 34

• • UniProt Entry

  • P24302,P80277

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiprotozoal

• • Target Organism

  • • Fungi: Microsporum canis (IP 1194) (MIC=50 µg/ml), Tricophyton rubrum (IP 1400-82) (MIC=100 µg/ml), Arthroderma simii (IP 1063-74) (MIC=100 µg/ml), Aspergillus fumigatus (IP 1025-70) (MIC=100 µg/ml), Aerornonas caviae IP (67-16) T (MIC=50 µg/ml), Cryptococcus neoformans (IP 960-67) (MIC=15 µg/ml), Cryptococcus neoformans (IP 962-67) (MIC=15 µg/ml), Candida albicans (IP 884-65) (MIC=60 µg/ml);
    • Gram-negative bacterium: Escherichia coli (IP 76-24) (MIC=5 µg/ml);
    • Gram-positive bacterium: Nocardia brasiliensis (IP 16-80) (MIC=200 µg/ml).

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Cell membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Alpha helix (CD)

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01668.

DRAMP01668

• • Function

  • Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. This peptide could also inhibit HIV infection at a concentration that is also toxic to T cells (J Virol 2005; 79

• • Tissue specificity

  • Expressed by the skin glands.

• ·Literature 1

• • Title

  • Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin.

• • Pubmed ID

  • 1909573

• • Reference

  • Biochemistry. 1991 Sep 10;30(36):8824-8830.

• • Author

  • Mor A, Nguyen VH, Delfour A, Migliore-Samour D, Nicolas P.

• ·Literature 2

• • Title

  • Isolation and structure of novel defensive peptides from frog skin.

• • Pubmed ID

  • 8306981

• • Reference

  • Eur J Biochem. 1994 Jan 15;219(1-2):145-154.

• • Author

  • Mor A, Nicolas P.