• • DRAMP ID

  • DRAMP01670

• • Peptide Name

  • Dermaseptin-3 (DS III; Dermaseptin-S3, DS3; Frogs, amphibians, animals)

• • Source

  • Phyllomedusa sauvagei (Sauvage's leaf frog)

• • Family

  • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

• • Gene

  • Not found

• • Sequence

  • ALWKNMLKGIGKLAGKAALGAVKKLVGAES

• • Sequence Length

  • 30

• • UniProt Entry

  • P80279

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Antifungal, Antiprotozoal

• • Target Organism

  • • [Ref.9395500]Fungi: Aspergillus fumigatus;
    • Protozoa: Malarial parasite strain H (IC50=0.8 µg/ml), Malarial parasite strain NF54 (IC50=0.26 µg/ml).

• • Hemolytic Activity

  • • [Ref:8306981]No significant hemolytic activity against rabbit red blood cells;
    • [Ref:9395500]Non-hemolytic activity against human red blood cells.

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Binds to healthy erythrocytes (this binding is receptor independent).

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Alpha helix

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01670.

DRAMP01670

• • Function

  • Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Probably acts by disturbing membrane functions with its amphipathic structure. Binds to healthy erythrocytes (this binding is receptor independent), but has no significant hemolytic activity. Does not bind to P. falciparum infected erythrocytes, but accumulates within the parasite. Kills the parasite, but has no hemolytic activity on the host cell.

• • Tissue specificity

  • Expressed by the skin glands.

• ·Literature 1

• • Title

  • Isolation and structure of novel defensive peptides from frog skin.

• • Pubmed ID

  • 8306981

• • Reference

  • Eur J Biochem. 1994 Jan 15;219(1-2):145-155.

• • Author

  • Mor A, Nicolas P.

• ·Literature 2

• • Title

  • Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis.

• • Pubmed ID

  • 9395500

• • Reference

  • J Biol Chem. 1997 Dec 12;272(50):31609-31616.

• • Author

  • Ghosh JK, Shaool D, Guillaud P, Cicéron L, Mazier D, Kustanovich I, Shai Y, Mor A.