• • DRAMP ID

  • DRAMP01671

• • Peptide Name

  • Dermaseptin-4 (DS IV; Dermaseptin-S4, DS4; Frogs, amphibians, animals)

• • Source

  • Phyllomedusa sauvagei (Sauvage's leaf frog)

• • Family

  • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

• • Gene

  • Not found

• • Sequence

  • ALWMTLLKKVLKAAAKALNAVLVGANA

• • Sequence Length

  • 27

• • UniProt Entry

  • P80280

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral

• • Target Organism

  • [Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1

• • Hemolytic Activity

  • • [Ref:11850249]IC50=20 μM against human erythrocytes

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • healthy erythrocytes (this binding is receptor independent).

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Combine strand and Turn structure

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01671.

DRAMP01671

• • Function

  • Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1. Probably acts by disturbing membrane functions with its amphipathic structure. Has strong hemolytic activity. Does not bind to P. falciparum infected erythrocytes, but accumulates within the parasite.

• • Tissue specificity

  • Expressed by the skin glands.

• • Pharmaceutical use

  • Derivatives of this peptide may be used as therapeutic agents to treat bacterial infections and malaria, and to prevent infection by herpes simplex virus type 1 and HIV-1.

• ·Literature 1

• • Title

  • Isolation and structure of novel defensive peptides from frog skin.

• • Pubmed ID

  • 8306981

• • Reference

  • Eur J Biochem. 1994 Jan 15;219(1-2):145-154.

• • Author

  • Mor A, Nicolas P.

• ·Literature 2

• • Title

  • Antibacterial properties of dermaseptin S4 derivatives with in vivo activity.

• • Pubmed ID

  • 11850249

• • Reference

  • Antimicrob Agents Chemother. 2002 Mar;46(3):689-694.

• • Author

  • Navon-Venezia S, Feder R, Gaidukov L, Carmeli Y, Mor A.

• ·Literature 3

• • Title

  • Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis.

• • Pubmed ID

  • 9395500

• • Reference

  • J Biol Chem. 1997 Dec 12;272(50):31609-31616.

• • Author

  • Ghosh JK, Shaool D, Guillaud P, Cicéron L, Mazier D, Kustanovich I, Shai Y, Mor A.