General Information
-
DRAMP ID
- DRAMP01676
-
Peptide Name
- Dermaseptin-4 (DStar 04; Frogs, amphibians, animals)
-
Source
- Phyllomedusa tarsius (Brownbelly leaf frog)
-
Family
- Belongs to the frog skin active peptide family (Dermaseptin subfamily)
-
Gene
- Not found
-
Sequence
- ALWKDILKNAGKAALNEINQIVQ
-
Sequence Length
- 23
-
UniProt Entry
- P84924
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- [Swiss_Prot Entry P84924]Gram-positive bacteria: Staphylococcus aureus, Enterococcus faecalis;
- Gram-neagtive bacterium: Pseudomonas aeruginosa.
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Hemolytic Activity
-
- [Ref:PubMed ID is not available]5% hemolytic activity at 128 µg/ml
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01676.
Physicochemical Information
-
Formula
- C115H192N32O33
Absent Amino Acids
- CFHMPRSTY
Common Amino Acids
- A
Mass
- 2550.98
PI
- 8.54
Basic Residues
- 3
Acidic Residues
- 2
Hydrophobic Residues
- 12
Net Charge
- +1
-
Boman Index
- -19.11
Hydrophobicity
- -0.052
Aliphatic Index
- 131.74
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 250
Polar Residues
- 4
DRAMP01676
Comments Information
Function
- Antimicrobial peptide, active against the Gram-positive bacterium S. aureus, the Gram-negative bacteria E. coli and P. aeruginosa. Has hemolytic activity.
Tissue specificity
- Expressed by the skin glands.
PTM
- C-terminal amidation.
Literature Information
- ·Literature 1
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Title
- Dermaseptins and phylloseptins from Phyllomedusa tarsius (Amphibia).
-
Pubmed ID
- PubMed ID is not available
-
Reference
- Submitted (AUG-2006) to UniProtKB.
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Author
- Prates M.V, Jardim D.P, Silva L.P, Gordo M, Leite J.R.S.A, Figueredo R.C.R, Amaral A.C, Felipe M.S.S, Bloch C. Jr.