General Information

    • DRAMP ID

    • DRAMP01700

    • Peptide Name

    • Dermaseptin-H3 (Dermaseptin-like peptide 3, DMS3; Frogs, amphibians, animals)

    • Source

    • Phyllomedusa azurea (Orange-legged monkey frog) (Phyllomedusa hypochondrialis azurea)

    • Family

    • Belongs to the frog skin active peptide family (Dermaseptin subfamily)

    • Gene

    • dpp-H3

    • Sequence

    • GLWSTIKNVAAAAGKAALGAL

    • Sequence Length

    • 21

    • Protein Existence

    • Transcript level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli;
      • Gram-positive bacteria: Staphylococcus aureus, Micrococcus luteus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01700 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01700.

Physicochemical Information

    • Formula

    • C90H151N25O25

    • Absent Amino Acids

    • CDEFHMPQRY

    • Common Amino Acids

    • A

    • Mass

    • 1983.34

    • PI

    • 10

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 13

    • Net Charge

    • +2

    • Boman Index

    • 17.83

    • Hydrophobicity

    • 0.848

    • Aliphatic Index

    • 121.43

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 275

    • Polar Residues

    • 6

DRAMP01700

DRAMP01700 chydropathy plot

Comments Information

    • MOA

    • Probably acts by disturbing membrane functions with its amphipathic structure (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • A combined mass spectrometric and cDNA sequencing approach to the isolation and characterization of novel antimicrobial peptides from the skin secretions of Phyllomedusa hypochondrialis azurea.

    • Reference

    • Peptides. 2007 Jul;28(7):1331-43.

    • Author

    • Thompson AH, Bjourson AJ, Orr DF, Shaw C, McClean S.