• DRAMP ID

    • DRAMP01734
    • Peptide Name

    • Temporin-ALg (Frogs, amphibians, animals)
    • Source

    • Amolops loloensis
    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)
    • Gene

    • Not found
    • Sequence

    • FFPIVGKLLFGLFGLL
    • Sequence Length

    • 16
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
    • Target Organism

      • [Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 µg/mL), Bacillus pumilus (MIC=2.5 µg/mL), Bacillus cereus (MIC=30 µg/mL);
      • Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 µg/mL), Bacillus dysenteriae (MIC=10 µg/mL), Acinetobacter calcoaceticus (MIC=30 µg/mL), Psecdomonas aeruginosa (MIC=7.5 µg/mL);
      • Yeast: Candida albicans ATCC2002 (MIC=1.25 µg/mL).
    • Hemolytic Activity

      • [Ref:19843479]16% hemolytic activity at 100 μg/mL against rabbit red blood cells.
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Amidation
    • Nonterminal Modifications and Unusual Amino Acids

    • Free
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP01734 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP01734.
    • Formula

    • C94H141N17O17
    • Absent Amino Acids

    • ACDEHMNQRSTWY
    • Common Amino Acids

    • L
    • Mass

    • 1781.26
    • PI

    • 8.75
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 11
    • Net Charge

    • +1
    • Boman Index

    • 42.75
    • Hydrophobicity

    • 2.013
    • Aliphatic Index

    • 164.38
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 0
    • Absorbance 280nm

    • 0
    • Polar Residues

    • 3

DRAMP01734

    • Function

    • Temporin-ALg exhibits hemolytic activity against rabbit red blood cells.
  • ·Literature 1
    • Title

    • Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis.
    • Reference

    • Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.
    • Author

    • Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R.