General Information
-
DRAMP ID
- DRAMP01735
-
Peptide Name
- Temporin-ALh (Frogs, amphibians, animals)
-
Source
- Amolops loloensis
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Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FLPIVGKLLSGLSGLS
-
Sequence Length
- 16
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
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Target Organism
-
- [Ref.19843479]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=2.5 µg/mL), Bacillus pumilus (MIC=7.5 µg/mL), Bacillus cereus (MIC=75 µg/mL);
- Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=5 µg/mL), Bacillus dysenteriae (MIC=20 µg/mL), Acinetobacter calcoaceticus (MIC=60 µg/mL), Psecdomonas aeruginosa (MIC=2.5 µg/mL);
- Yeast: Candida albicans ATCC2002 (MIC=2.5 µg/mL).
-
Hemolytic Activity
-
- [Ref:19843479]13% hemolytic activity at 100 μg/mL against rabbit red blood cells.
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01735.
Physicochemical Information
-
Formula
- C76H129N17O20
Absent Amino Acids
- ACDEHMNQRTWY
Common Amino Acids
- L
Mass
- 1600.96
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- 23.61
Hydrophobicity
- 1.338
Aliphatic Index
- 164.38
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 6
DRAMP01735
Comments Information
Function
- Temporin-ALh exhibits hemolytic activity against rabbit red blood cells.
Literature Information
- ·Literature 1
-
Title
- Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis.
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Pubmed ID
- 19843479
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Reference
- Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.
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Author
- Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R.