• • DRAMP ID

  • DRAMP01738

• • Peptide Name

  • Temporin-ALk (Frogs, amphibians, animals)

• • Source

  • Amolops loloensis

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FFPIVGKLLS

• • Sequence Length

  • 10

• • UniProt Entry

  • No entry found

• • Protein Existence

  • Not found

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

• • Target Organism

  • • [Ref.19843479]Gram-positive bacterium: Staphylococcus aureus ATCC2592 (MIC=15 µg/mL);
    • Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=30 µg/mL), Bacillus dysenteriae (MIC=60 µg/mL), Acinetobacter calcoaceticus (MIC=75 µg/mL), Psecdomonas aeruginosa (MIC=25 µg/mL);
    • Yeast: Candida albicans ATCC2002 (MIC=15 µg/mL).

• • Hemolytic Activity

  • • [Ref:19843479]25% hemolytic activity at 100 μg/mL against rabbit red blood cells.

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01738.

DRAMP01738

• • Function

  • Temporin-ALk exhibits hemolytic activity against rabbit red blood cells.

• ·Literature 1

• • Title

  • Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis.

• • Pubmed ID

  • 19843479

• • Reference

  • Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-76.

• • Author

  • Wang M, Wang Y, Wang A, Song Y, Ma D, Yang H, Ma Y, Lai R.