General Information
-
DRAMP ID
- DRAMP01740
-
Peptide Name
- Temporin-C (Frogs, amphibians, animals)
-
Source
- Rana temporaria (European common frog)
-
Family
- Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
-
Gene
- Not found
-
Sequence
- LLPILGNLLNGLL
-
Sequence Length
- 13
-
UniProt Entry
- P56918
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01740.
Physicochemical Information
-
Formula
- C65H115N15O16
Absent Amino Acids
- ACDEFHKMQRSTVWY
Common Amino Acids
- L
Mass
- 1362.72
PI
- 5.52
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- 0
-
Boman Index
- 27.96
Hydrophobicity
- 1.669
Aliphatic Index
- 240
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP01740
Comments Information
Function
- Antibacterial activity against Gram-positive bacteria.
PTM
- Leucine amide at position 13.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
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Title
- Temporins, antimicrobial peptides from the European red frog Rana temporaria.
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Pubmed ID
- 9022710
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Reference
- Eur J Biochem. 1996 Dec 15;242(3):788-792.
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Author
- Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.