General Information
-
DRAMP ID
- DRAMP01744
-
Peptide Name
- Temporin-G (Frogs, amphibians, animals)
-
Source
- Rana temporaria (European common frog)
-
Family
- Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
-
Gene
- Not found
-
Sequence
- FLPLIGKVLSGIL
-
Sequence Length
- 13
-
UniProt Entry
- P79875
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
- No MICs found in DRAMP database
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01744.
Physicochemical Information
-
Formula
- C72H115N17O15
Absent Amino Acids
- ACDEHKMQSTWY
Common Amino Acids
- I
Mass
- 1458.81
PI
- 9.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- 14.92
Hydrophobicity
- 1.577
Aliphatic Index
- 172.31
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP01744
Comments Information
Function
- Antibacterial activity against Gram-negative and Gram-positive bacteria.
PTM
- Leucine amide at position 13.
Tissue specificity
- Expressed by the skin glands.
Literature Information
- ·Literature 1
-
Title
- Temporins, antimicrobial peptides from the European red frog Rana temporaria.
-
Pubmed ID
- 9022710
-
Reference
- Eur J Biochem. 1996 Dec 15;242(3):788-792.
-
Author
- Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.