General Information

    • DRAMP ID

    • DRAMP01745

    • Peptide Name

    • Temporin-K (Frogs, amphibians, animals)

    • Source

    • Rana temporaria (European common frog)

    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.

    • Gene

    • Not found

    • Sequence

    • LLPNLLKSLL

    • Sequence Length

    • 10

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01745 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01745.

Physicochemical Information

    • Formula

    • C54H98N12O13

    • Absent Amino Acids

    • ACDEFGHIMQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1123.44

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • 13.93

    • Hydrophobicity

    • 1.3

    • Aliphatic Index

    • 234

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP01745

Comments Information

    • Function

    • Antibacterial activity against Gram-positive bacteria.

Literature Information

  • ·Literature 1

    • Title

    • Temporins, antimicrobial peptides from the European red frog Rana temporaria.

    • Reference

    • Eur J Biochem. 1996 Dec 15;242(3):788-792.

    • Author

    • Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.