• DRAMP ID

    • DRAMP01746
    • Peptide Name

    • Temporin-L (Temporin-1Tl; temporin-Tl; TL; Frogs, amphibians, animals)
    • Source

    • Rana temporaria (European common frog)
    • Family

    • Belongs to the frog skin active peptide (FSAP) family. Brevinin subfamily.
    • Gene

    • Unknown
    • Sequence

    • FVQWFSKFLGRIL
    • Sequence Length

    • 13
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Anti-Gram-, Antiparasitic, Anticancer., Antimicrobial
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Unknown
    • Structure

    • Alpha helix
    • Structure Description

    • Unknownn
    • PDB ID

    • 6GS5 resolved by NMR.
    • DRAMP01746 helical wheel diagram
    • Formula

    • C83H121N19O16
    • Absent Amino Acids

    • ACDEHMNPTY
    • Common Amino Acids

    • F
    • Mass

    • 1855.21
    • PI

    • 11.65
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Boman Index

    • 1.6
    • Hydrophobicity

    • 82.31
    • Aliphatic Index

    • 112.31
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 5500
    • Absorbance 280nm

    • 458.33
    • Polar Residues

    • 2

DRAMP01746

    • Function

    • Antibacterial activity against Gram-negative and Gram-positive bacteria.
    • PTM

    • Leucine amide at position 13.
    • Tissue specificity

    • Expressed by the skin glands.
  • Literature 1
    • Reference

    • Eur J Biochem. 1996 Dec 15;242(3):788-792.
    • Author

    • Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D.
    • Title

    • Temporins, antimicrobial peptides from the European red frog Rana temporaria.