• • DRAMP ID

  • DRAMP01748

• • Peptide Name

  • Temporin-AJ8 (Frogs, amphibians, animals)

• • Source

  • Amolops jingdongensis (torrent frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • FFPIVGKRLYGLL

• • Sequence Length

  • 13

• • UniProt Entry

  • K7Z903

• • Protein Existence

  • Transcript level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.22828809] Gram-negative bacteria: Escherichia coli ATCC 25922(MIC=70 μg/ml), B. dysenteriae(MIC=18.75 μg/ml) ;
    • Gram-positive bacteria: Staphylococcus aureus ATCC 2592(MIC=4.7 μg/ml), Bacillus subtilis ATCC 6633(MIC=9.38 μg/ml);
    • Yeast: Candida albicans ATCC 2002(MIC=37.5 μg/ml).

• • Hemolytic Activity

  • • [Ref.22828809] 1.79% hemolysis at 25μg/ml, 5.22% hemolysis at 50μg/ml, 7.92% hemolysis at 100μg/ml, 10.85% hemolysis at 200μg/ml against rabbit red blood cells

• • Cytotoxicity

  • • Not included yet

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Not included yet

• • N-terminal Modification

  • Not included yet

• • C-terminal Modification

  • Not included yet

• • Nonterminal Modifications and Unusual Amino Acids

  • Not included yet

• • Stereochemistry

  • Not included yet

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01748.

DRAMP01748

• • Function

  • Shows antimicrobial abilities against microorganisms including Gram-negative and Gram-positive bacteria, and fungi. Has hemolytic activity.

• ·Literature 1

• • Title

  • Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis.

• • Pubmed ID

  • 22828809

• • Reference

  • Amino Acids. 2012 Jul 25.

• • Author

  • He X, Yang S, Wei L, Liu R, Lai R, Rong M.