General Information

    • DRAMP ID

    • DRAMP01754

    • Peptide Name

    • Temporin-1CEb (Frogs, amphibians, animals)

    • Source

    • Rana chensinensis (Chinese brown frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • ILPILSLIGGLLGK

    • Sequence Length

    • 14

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=41 µM), Bacillus cereus (MIC=41 µM), Streptococcus lactis (MIC=41 µM);
      • Gram-negative bacterium: Escherichia coli (MIC>100 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01754 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01754.

Physicochemical Information

    • Formula

    • C68H123N15O16

    • Absent Amino Acids

    • ACDEFHMNQRTVWY

    • Common Amino Acids

    • L

    • Mass

    • 1406.82

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +1

    • Boman Index

    • 33.23

    • Hydrophobicity

    • 1.786

    • Aliphatic Index

    • 222.86

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01754

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis.

    • Reference

    • Zoolog Sci. 2009 Mar;26(3):220-226.

    • Author

    • Shang D, Yu F, Li J, Zheng J, Zhang L, Li Y.