General Information
-
DRAMP ID
- DRAMP01759
-
Peptide Name
- Temporin-1SPb (Frogs, amphibians, animals)
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Source
- Rana septentrionalis (mink frog)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FLSAITSLLGKLL
-
Sequence Length
- 13
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus (MIC=6 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01759.
Physicochemical Information
-
Formula
- C66H114N14O17
Absent Amino Acids
- CDEHMNPQRVWY
Common Amino Acids
- L
Mass
- 1375.71
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- 20.33
Hydrophobicity
- 1.654
Aliphatic Index
- 187.69
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP01759
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Purification and characterization of antimicrobial peptides from the skin secretions of the mink frog (Rana septentrionalis).
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Pubmed ID
- 15556063
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Reference
- Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):31-38.
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Author
- Bevier CR, Sonnevend A, Kolodziejek J, Nowotny N, Nielsen PF, Conlon JM.