General Information
-
DRAMP ID
- DRAMP01764
-
Peptide Name
- Temporin-1TGa (Frogs, amphibians, animals)
-
Source
- Rana tagoi (Tago frog)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- tmpTGa
-
Sequence
- FLPILGKLLSGIL
-
Sequence Length
- 13
-
UniProt Entry
- Q2PGA8
-
Protein Existence
- Homology
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
-
Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus (MIC=15 µM);
- Gram-negative bacterium: Escherichia coli (MIC>100 µM).
- Yeast: Candida albicans.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01764.
Physicochemical Information
-
Formula
- C69H118N14O15
Absent Amino Acids
- ACDEHMNQRTVWY
Common Amino Acids
- L
Mass
- 1383.78
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 8
Net Charge
- +1
-
Boman Index
- 30.35
Hydrophobicity
- 1.823
Aliphatic Index
- 210
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP01764
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties.
-
Pubmed ID
- 12804591
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Reference
- Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500.
-
Author
- Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pál T.
- ·Literature 2
-
Title
- Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi.
-
Pubmed ID
- 16675060
-
Reference
- Peptides. 2006 Sep;27(9):2124-2128.
-
Author
- Iwamuro S, Nakamura M, Ohnuma A, Conlon JM.