General Information

    • DRAMP ID

    • DRAMP01765

    • Peptide Name

    • Temporin-1TGb (Frogs, amphibians, animals)

    • Source

    • Rana tagoi (Tago frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • tmpTGb

    • Sequence

    • AVDLAKIANKVLSSLF

    • Sequence Length

    • 16

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-positive bacterium: Staphylococcus aureus (MIC>150 µM);
      • Gram-negative bacterium: Escherichia coli (MIC=37.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01765 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C78H133N19O22

    • Absent Amino Acids

    • CEGHMPQRTWY

    • Common Amino Acids

    • AL

    • Mass

    • 1689.03

    • PI

    • 8.64

    • Basic Residues

    • 2

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +1

    • Boman Index

    • 2.91

    • Hydrophobicity

    • 1.006

    • Aliphatic Index

    • 152.5

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 3

DRAMP01765

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Molecular cloning and sequence analyses of preprotemporin mRNAs containing premature stop codons from extradermal tissues of Rana tagoi.

    • Reference

    • Peptides. 2006 Sep;27(9):2124-2128.

    • Author

    • Iwamuro S, Nakamura M, Ohnuma A, Conlon JM.