General Information
-
DRAMP ID
- DRAMP01768
-
Peptide Name
- Temporin-1SKa (Frogs, amphibians, animals)
-
Source
- Rana sakuraii (stream brown frog)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- Not found
-
Sequence
- FLPVILPVIGKLLNGIL
-
Sequence Length
- 17
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
-
Target Organism
-
- Gram-negative bacteria: Escherichia coli (MIC>50 µM);
- Gram-negative bacteria: Staphylococcus aureus (MIC=25 µM).
- Fungi: Candida albicans (MIC>50 µM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01768.
Physicochemical Information
-
Formula
- C91H155N19O19
Absent Amino Acids
- ACDEHMQRSTWY
Common Amino Acids
- L
Mass
- 1819.35
PI
- 8.75
Basic Residues
- 1
Acidic Residues
- 0
Hydrophobic Residues
- 11
Net Charge
- +1
-
Boman Index
- 40.11
Hydrophobicity
- 1.9
Aliphatic Index
- 217.65
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 3
DRAMP01768
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Expression of genes encoding antimicrobial and bradykinin-related peptides in skin of the stream brown frog Rana sakuraii.
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Pubmed ID
- 17174009
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Reference
- Peptides. 2007 Mar;28(3):505-514.
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Author
- Suzuki H, Iwamuro S, Ohnuma A, Coquet L, Leprince J, Jouenne T, Vaudry H, Taylor CK, Abel PW, Conlon JM.