General Information
-
DRAMP ID
- DRAMP01779
-
Peptide Name
- Temporin-SHf (Frogs, amphibians, animals)
-
Source
- Pelophylax saharicus (Sahara frog) (Rana saharica)
-
Family
- Belongs to the frog skin active peptide family (Brevinin subfamily)
-
Gene
- preproTemp-SHf
-
Sequence
- FFFLSRIFGK
-
Sequence Length
- 10
-
UniProt Entry
- D4YWD1
-
Protein Existence
- Transcript level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
-
Target Organism
-
- Gram-positive bacterium: Staphylococcus aureus (MIC=12.5 µM);
- Gram-negative bacterium: Escherichia coli (MIC=25-200 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- Free
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP01779.
Physicochemical Information
-
Formula
- C65H92N14O12
Absent Amino Acids
- ACDEHMNPQTVWY
Common Amino Acids
- F
Mass
- 1261.53
PI
- 11
Basic Residues
- 2
Acidic Residues
- 0
Hydrophobic Residues
- 6
Net Charge
- +2
-
Boman Index
- -1.17
Hydrophobicity
- 0.99
Aliphatic Index
- 78
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 2
DRAMP01779
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Temporin-SHf, a new type of phe-rich and hydrophobic ultrashort antimicrobial peptide.
-
Pubmed ID
- 20308076
-
Reference
- J Biol Chem. 2010 May 28;285(22):16880-16892.
-
Author
- Abbassi F, Lequin O, Piesse C, Goasdoue N, Foulon T, Nicolas P, Ladram A.