General Information

    • DRAMP ID

    • DRAMP01780

    • Peptide Name

    • Temporin-SHa (Temporin-1Sa; Frogs, amphibians, animals)

    • Source

    • Pelophylax saharica (North Africa)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FLSGIVGMLGKLF

    • Sequence Length

    • 13

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=3 µM), Bacillus megaterium (MIC=2 µM);
      • Gram-negative bacterium: Escherichia coli (MIC=10 µM).
      • Yeast: Candida albicans (MIC=16 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.31614561]Display cytotoxic against human gastric cells(N87 cell:IC50=1558 ± 324μM)

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Alpha helix

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01780 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C67H108N14O15S

    • Absent Amino Acids

    • ACDEHNPQRTWY

    • Common Amino Acids

    • GL

    • Mass

    • 1381.74

    • PI

    • 8.75

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • 25.9

    • Hydrophobicity

    • 1.669

    • Aliphatic Index

    • 142.31

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01780

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori.

    • Reference

    • Biomolecules. 2019 Oct 11;9(10):598.

    • Author

    • Olleik H, Baydoun E, Perrier J, Hijazi A, Raymond J, Manzoni M, Dupuis L, Pauleau G, Goudard Y, Villéon B, Goin G, Sockeel P, Choudhary MI, Pasquale ED, Nadeem-Ul-Haque M, Ali H, Khan AI, Shaheen F, Maresca M.