General Information

    • DRAMP ID

    • DRAMP01783

    • Peptide Name

    • Temporin-LTb (Frogs, amphibians, animals)

    • Source

    • Hylarana latouchii (broad-folded frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • FIITGLVRGLTKLF

    • Sequence Length

    • 14

    • Protein Existence

    • Homology

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=12.5 µg/ml) and Bacillus subtilis (MIC=25 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Cell membrance

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01783 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01783.

Physicochemical Information

    • Formula

    • C77H128N18O17

    • Absent Amino Acids

    • ACDEHMNPQSWY

    • Common Amino Acids

    • L

    • Mass

    • 1577.97

    • PI

    • 11

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +2

    • Boman Index

    • 10.87

    • Hydrophobicity

    • 1.4

    • Aliphatic Index

    • 160

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP01783

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae).

    • Reference

    • Peptides. 2009 Feb;30(2):273-282.

    • Author

    • Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J.