General Information

    • DRAMP ID

    • DRAMP01784

    • Peptide Name

    • Temporin-LTc (Frogs, amphibians, animals)

    • Source

    • Hylarana latouchii (broad-folded frog)

    • Family

    • Belongs to the frog skin active peptide family (Brevinin subfamily)

    • Gene

    • Not found

    • Sequence

    • SLSRFLSFLKIVYPPAF

    • Sequence Length

    • 17

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antiviral

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus (MIC=50 µg/ml), Bacillus subtilis (MIC=50 µg/ml);
      • Gram-negative bacterium: Pseudomonas fluorescens (MIC=100 µg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • Free

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP01784 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP01784.

Physicochemical Information

    • Formula

    • C99H149N21O22

    • Absent Amino Acids

    • CDEGHMNQTW

    • Common Amino Acids

    • FLS

    • Mass

    • 1985.4

    • PI

    • 9.99

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +2

    • Boman Index

    • 3.66

    • Hydrophobicity

    • 0.882

    • Aliphatic Index

    • 114.71

    • Half Life

      • Mammalian:1.9 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 1490

    • Absorbance 280nm

    • 93.13

    • Polar Residues

    • 4

DRAMP01784

Comments Information

    • Comment

    • A mutant of the peptide is also HIV inhibitory (Wang G et al. 2010 Antimicrob. Agents Chemother. 54

Literature Information

  • ·Literature 1

    • Title

    • The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae).

    • Reference

    • Peptides. 2009 Feb;30(2):273-282.

    • Author

    • Wang H, Lu Y, Zhang X, Hu Y, Yu H, Liu J, Sun J.