• • DRAMP ID

  • DRAMP01787

• • Peptide Name

  • Temporin-HN1 (Frogs, amphibians, animals)

• • Source

  • Odorrana hainanensis (Hainan odorous frog)

• • Family

  • Belongs to the frog skin active peptide family (Brevinin subfamily)

• • Gene

  • Not found

• • Sequence

  • AILTTLANWARKFL

• • Sequence Length

  • 14

• • UniProt Entry

  • E7EKD0

• • Protein Existence

  • Protein level

• • Biological Activity

  • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal

• • Target Organism

  • • [Ref.22450466]Gram-positive bacteria: Staphylococcus aureus ATCC2592 (MIC=37.5 µM), Staphylococcus carnosus KHS (MIC=37.5 µM), Bacillus licheniformis X39 (MIC=19 µM), Rhodococcus rhodochrous X15 (MIC=4.8 µM);
    • Gram-negative bacteria: Psychrobacter faecalis X29 (MIC=75 µM);
    • Fungi: Slime mould 090223 (MIC=19 µM), Candida albicans ATCC2002 (MIC=75 µM).

• • Hemolytic Activity

  • • [Ref:22450466]IC50=75 µM against washed human erythrocytes

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • Not found

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Amidation

• • Nonterminal Modifications and Unusual Amino Acids

  • Free

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • Helical Wheel Diagram

  • 

• • PDB ID

  • None

• Predicted Structure

• There is no predicted structure for DRAMP01787.

DRAMP01787

• • Function

  • Has hemolytic activity against washed human erythrocytes (IC50=75 µM).

• ·Literature 1

• • Title

  • Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis.

• • Pubmed ID

  • 22450466

• • Reference

  • Peptides. 2012 Jun;35(2):285-290.

• • Author

  • Wang H, Yu Z, Hu Y, Li F, Liu L, Zheng H, Meng H, Yang S, Yang X, Liu J.